This study was undertaken to determine if Juglandis Semen Aquacupuncture(Ja) has a protective effect against glycerol-induced acute renal failure in rats. Rats were dehydrated for 24hr and then injected with 5 ㎖/㎏ of 50% glycerol, one-half of dose in each hindlimb muscle. In experiments for Ja effect, rats received 0.1 ㎖ of Ja extraction in both sides of corresponding She｀nsu￣(BL_(23)) of human body and non-acupuncture points(the root of tail) for 3 days after injection of glycerol. The experimental group were divided into the Normal group, the Control group, the Ja to She｀nsu￣(BL_(23)) group(Ja-AS), the Ja to non-acupuncture points group(Ja-AN).
There were significant decrease of Urine vollume, total protein and phosphate level in Ja-AS as compared with the control group. There were not any significant change of Urine creatinine in Ja-AS as compared with the control group. There were significant decrease of Unine glucose in Ja-AS, Ja-AN as compared with the control group.
This suggests that Ja-AS could be used in prevention and treatment of acute renal failure. However, the precise mechanisms of Ja protection remain to be determined.
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